Unlocking Audio

Unlocking Energy

Locks are a natural place for improving the energy efficiency of software systems. First, concurrent systems are mainstream and when their threads synchronize, they typically do it with locks. Second, locks are well-defined abstractions, hence changing the algorithm implementing them can be achieved without modifying the system. Third, some locking strategies consume more power than others, thu...

Unlocking the DOR Code

of the retina. At first glance, it would seem improbable studies that have revealed the basic mechanisms by that full-fledged sodium action potentials would play a which odorant information in the periphery is reliably major role. Thus, the first stages of retinal processing transferred to the brain for higher order processing. are likely to remain analog rather than digital. However, The initi...

Unlocking SOAR releases STIM.

A crucial component of the receptor-evoked Ca(2+) signal is Ca(2+) influx mediated by the store-operated Ca(2+) channels (SOCs). The molecular makeup of one SOC is the endoplasmic reticulum (ER) Ca(2+) sensor STIM1 and the pore-forming Orai1. Ca(2+) release from the ER leads to co-clustering of STIM1 and Orai1 to activate Orai1. The short STIM1 SOAR/CAD domain (STIM1 Orai1-activating region/CRA...

Unlocking ATP13A2/PARK9 activity.

Unlocking hidden genomic sequence.

Despite the success of conventional Sanger sequencing, significant regions of many genomes still present major obstacles to sequencing. Here we propose a novel approach with the potential to alleviate a wide range of sequencing difficulties. The technique involves extracting target DNA sequence from variants generated by introduction of random mutations. The introduction of mutations does not d...